Search Result

Results for "

tyrosinase activity

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Tyrosinase (46) AMPK (1) Apoptosis (2) Autophagy (4) Bacterial (5) COX (1) DNA/RNA Synthesis (1) Elastase (1) Fungal (2) HDAC (1) Interleukin Related (2) Isotope-Labeled Compounds (4) MAPKAPK2 (MK2) (1) Melanocortin Receptor (3) Parasite (1) PPAR (1) Raf (1) Ras (1) Reactive Oxygen Species (1) TGF-beta/Smad (1) TNF Receptor (2)
By Research Areas:	Cancer (15) Infection (9) Inflammation/Immunology (11) Metabolic Disease (12) Neurological Disease (2)

Inhibitors & Agonists

Peptides

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: Tyrosinase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-161289

Tyrosinase-IN-24

Tyrosinase Cancer

Tyrosinase-IN-24 (compound 3b) is a tyrosinase inhibitor with inhibitory activity against mushroom tyrosinase .

Tyrosinase-IN-24	Tyrosinase	Cancer
Tyrosinase-IN-24 (compound 3b) is a tyrosinase inhibitor with inhibitory activity against mushroom tyrosinase .

HY-155247

Tyrosinase-IN-14	Tyrosinase	Others
Tyrosinase-IN-14 (compound 7m) is a tyrosinase inhibitor that reduces the catalytic activity of tyrosinase by changing its secondary structure. Tyrosinase-IN-14 has low cytotoxicity and anti-browning activity in fruits. Tyrosinase-IN-14 effectively inhibits banana browning during storage .

HY-157124

Tyrosinase-IN-19	Tyrosinase	Metabolic Disease
Tyrosinase-IN-19 (compound 9) is a competitive *tyrosinase* inhibitor. Tyrosinase-IN-19 has strong antioxidant activities against ROS, ABTS+, and DPPH radicals. Tyrosinase-IN-19 suppresses tyrosinase expression in a dose-dependent manner .

HY-149207

Tyrosinase-IN-11	Tyrosinase	Metabolic Disease
Tyrosinase-IN-11 is a potent *tyrosinase* inhibitor with IC₅₀s of 50 nM and 64 nM for L-tyrosinase and L-dopa, respectively. Tyrosinase-IN-11 has significant antioxidant activity and low cytotoxicity. Tyrosinase-IN-11 has the potential for skin hyperpigmentation research .

HY-157123

Tyrosinase-IN-18	Tyrosinase	Others
Tyrosinase-IN-18 (compound 6) is a potent tyrosinase inhibitor. Tyrosinase-IN-18 has strong antioxidant activities against ROS, ABTS+, and DPPH radicals .

HY-152194

Tyrosinase-IN-10	Tyrosinase	Cancer
Tyrosinase-IN-10 (Compound 23) is a partially competitive *tyrosinase* inhibitor with an IC₅₀ of 1.6 μM against tyrosinase activity from human melanoma cell lysates .

HY-143206

Tyrosinase/elastase-IN-1

Elastase Others

Tyrosinase/elastase-IN-1 a triterpenoid from Rubus fraxinifolius leaves, has tyrosinase and elastase inhibitory activities.

Tyrosinase/elastase-IN-1	Elastase	Others
Tyrosinase/elastase-IN-1 a triterpenoid from Rubus fraxinifolius leaves, has tyrosinase and elastase inhibitory activities.

HY-149404

Tyrosinase-IN-12	Reactive Oxygen Species Tyrosinase	Others
Non-competitive tyrosinase inhibitor (Tyrosinase-IN-12) is a potent, non-competitive *tyrosinase* inhibitor with an IC₅₀ value of 49.33 ± 2.64 µM and K_i value of 31.25 ± 0.25 µM. Non-competitive tyrosinase inhibitor (Tyrosinase-IN-12) have the highest radical scavenging activity to reduce the production of reactive oxygen species (ROS) with an IC₅₀ value of 25.39 ± 0.77 µM. Non-competitive tyrosinase inhibitor (Tyrosinase-IN-12) can be used for anti-browning substances in the food and agricultural sectors .

HY-N6244

Isolindleyin	Tyrosinase	Inflammation/Immunology
Isolindleyin, a butyrophenone, is a *tyrosinase* inhibitor, with a K_d of 54.8 μM for human tyrosinase. Isolindleyin exhibits anti-inflammatory, analgesic and anti-melanogenic activities .

HY-N3091

Persiconin	Tyrosinase	Others
Persiconin is a tyrosinase Inhibitor. Persiconin can be isolated from Prunus persica. Persiconin has tyrosinase inhibitory activity of 46% at 500 μM. Persiconin can be used in whitening research .

HY-N3200

Neorauflavane	Tyrosinase	Cancer
Neorauflavane is a potent *tyrosinase* inhibitor derived from Campylotropis hirtella, with an IC₅₀ value of 30 nM for tyrosinase monophenolase activity and an IC₅₀ value of 500 nM for diphenolase activity. Neorauflavane can effectively reduce the melanin content of B16 melanoma cells .

HY-N2204

Swertiajaponin
Swertiajaponin is a tyrosinase inhibitor, forms multiple hydrogen bonds and hydrophobic interactions with the binding pocket of tyrosinase, with an IC₅₀ of 43.47 μM. Swertiajaponin also inhibits oxidative stress-mediated MAPK/MITF signaling, leading to decrease in tyrosinase protein level. Swertiajaponin suppresses melanin accumulation and exhibits strong anti-oxidative activity .

HY-139857

Piceid 6″-O-azelaic acid ester

Tyrosinase Others

Piceid 6″-O-azelaic acid ester shows high intracellular tyrosinase inhibitory and depigmentating activities.
HY-N10286

Chetoseminudin B

Tyrosinase Others

Chetoseminudin B possesses mushroom tyrosinase inhibitory activity with IC₅₀ of 31.7 μM .
HY-N7929

5-Feruloylquinic acid

Tyrosinase Cancer

5-Feruloylquinic acid (5-FQA) possesses antioxidative effects and tyrosinase inhibitory activities .

Piceid 6″-O-azelaic acid ester	Tyrosinase	Others
Piceid 6″-O-azelaic acid ester shows high intracellular tyrosinase inhibitory and depigmentating activities.

Chetoseminudin B	Tyrosinase	Others
Chetoseminudin B possesses mushroom tyrosinase inhibitory activity with IC₅₀ of 31.7 μM .

5-Feruloylquinic acid	Tyrosinase	Cancer
5-Feruloylquinic acid (5-FQA) possesses antioxidative effects and tyrosinase inhibitory activities .

HY-B1461

Deoxyarbutin	Tyrosinase	Others
Deoxyarbutin can effectively inhibit tyrosinase activity and melanin synthesis, thereby achieving significant and lasting whitening effects, and has a strong antioxidant effect.

HY-147709

Tyrosinase-IN-6

Tyrosinase Others

Compound 4B proved to be the most effective tyrosinase inhibitor (ic₅₀= 3.80 μ M) It also showed good antioxidant activity.

Tyrosinase-IN-6	Tyrosinase	Others
Compound 4B proved to be the most effective tyrosinase inhibitor (ic₅₀= 3.80 μ M) It also showed good antioxidant activity.

HY-N3943

Glabrene	Tyrosinase	Neurological Disease
Glabrene, an isoflavene derived from licorice root, shows estrogen-like activity. Glabrene is a *tyrosinase* inhibitor with an IC₅₀ of 3.5 μM .

HY-N3912

Furomollugin	Bacterial	Infection Cancer
Furomollugin is a natural product with antioxidant and antibacterial activities, can be isolated from Rubia cordifolia. Furomollugin lacks potent anti-tyrosinase activity, but also exhibits significant anticancer property .

HY-N1238

β-Sitostenone Δ4-Sitosterol-3-one; β-Rosasterol oxide
β-Sitostenone is a sterols that can be isolated from Cochlospermum vitifolium.β-Sitostenone inhibits *tyrosinase* activity, and has anti-melanogenic and anti-tumor activities .

HY-126052

Gnetol	COX Tyrosinase HDAC	Metabolic Disease Cancer
Gnetol is a phenolic compound isolated from the root of Gnetum montanum . Gnetol potently inhibits COX-1 (IC₅₀ of 0.78 μM) and HDAC. Gnetol is a potent *tyrosinase* inhibitor with an IC₅₀ of 4.5 μM for murine tyrosinase and suppresses melanin biosynthesis. Gnetol has antioxidant, antiproliferative, anticancer and hepatoprotective activity. Gnetol also possesses concentration-dependent α-Amylase, α-glucosidase, and adipogenesis activities .

HY-117761

MHY908

PPAR Metabolic Disease Cancer

MHY908 is a potent dual agonist of PPARα and PPARγ . MHY908 also inhibits melanogenesis through inhibition of mushroom tyrosinase activity .

MHY908	PPAR	Metabolic Disease Cancer
MHY908 is a potent dual agonist of PPARα and PPARγ . MHY908 also inhibits melanogenesis through inhibition of mushroom tyrosinase activity .

HY-N3773

Dodoviscin A	Tyrosinase	Cancer
Dodoviscin A is a pigmentation-altering agent, which can be isolated from the aerial parts of Dodonaea viscosa. Dodoviscin A inhibits melanin production in B16-F10 melanoma cells. Dodoviscin A suppresses mushroom tyrosinase activity, and **tyrosinase activity induced by 3-isobutyl-1-methylxanthine. Dodoviscin A also inhibits the phorphosylation of cAMP response element binding protein**, induced by 3-isobutyl-1-methylxanthine and forskolin .

HY-N0616

Trifolirhizin	Tyrosinase	Inflammation/Immunology Cancer
Trifolirhizin is a pterocarpan flavonoid isolated from the roots of Sophora flavescens. Trifolirhizin possesses potent *tyrosinase* inhibitory activity with an IC₅₀ of 506 μM . Trifolirhizin exhibits potential anti-inflammatory and anticancer activities .

HY-N2460

Aloesin 1 Publications Verification Aloeresin	Tyrosinase Apoptosis	Infection Inflammation/Immunology Cancer
Aloesin (Aloeresin) is a *tyrosinase* inhibitor, and shows anti-inflammatory activity, ultraviolet protection, and antibacterium effects. Aloesin can induce apoptosis and be used in ovarian cancer research .

HY-N3674

Dalbergioidin	TGF-beta/Smad	Inflammation/Immunology
Dalbergioidin, a well-known anthocyanin, ameliorates doxorubicin-induced renal fibrosis by suppressing the TGF-β signal pathway. Dalbergioidin exhibits tyrosinase inhibitory activity with an IC₅₀ of 20 mM .

HY-N7587

Chlorophorin	Melanocortin Receptor	Metabolic Disease
Chlorophorin is a inhibitor of Melanocortin Receptor. Chlorophorin reduces tyrosinase activity and inhibits a-melanocyte-stimulating hormone-induced melanin production in B16F10 melanoma cells .

HY-N10285

Phaeosphaone D	Tyrosinase	Infection
Phaeosphaone D is a thiodiketopiperazine alkaloid compound isolated from Phaeosphaeria fuckelii, an endophytic fungus. Phaeosphaone D displays mushroom tyrosinase inhibitory activity with an IC₅₀ value of 33.2 μM .

HY-Y0729

4-Chlorocinnamic acid	Tyrosinase Bacterial Fungal	Infection
4-Chlorocinnamic acid has inhibitory effects on *tyrosinase. 4-Chlorocinnamic acid has antibacterial activity. 4-Chlorocinnamic acid also inhibits Colletotrichum gloeosporioides* growth .

HY-W019829

Polyphyllin C	Tyrosinase Parasite	Infection
Polyphyllin C (compound 2) is a spirostanol saponin. Polyphyllin C exhibits mild (IC₅₀=36.87 µM) activities against the *tyrosinase* and moderate (IC₅₀=1.59 µg/mL) antileishmanial activities .

HY-N0136

Taxifolin Maximum Cited Publications 11 Publications Verification (+)-Dihydroquercetin; (+)-Taxifolin	Autophagy Tyrosinase	Inflammation/Immunology
Taxifolin ((+)-Dihydroquercetin) exhibits important anti-tyrosinase activity. Taxifolin exhibits significant inhibitory activity against collagenase with an IC₅₀ value of 193.3 μM . Taxifolin is an important natural compound with antifibrotic activity. Taxifolin is a free radical scavenger with antioxidant capacity .

HY-N0637A

(±)-Eriodictyol (±)-Huazhongilexone; Dihydroluteolin	Melanocortin Receptor	Metabolic Disease
(±)-Eriodictyol ((±)-Huazhongilexone), a flavonoid, is a potent melanogenesis inhibitor with an IC₅₀ of 48 μM. (±)-Eriodictyol suppresses tyrosinase, TRP-1, and TRP-2 mRNA expression. (±)-Eriodictyol has strong anti-plasmin activities .

HY-N3518

Mulberroside F	Tyrosinase	Metabolic Disease
Mulberroside F is one of the main bioactive constituents in mulberry (Morus alba L.) . Mulberroside F shows inhibitory effects on *tyrosinase* activity and on the melanin formation. Mulberroside F also exhibits superoxide scavenging activity that is involved in the protection against auto-oxidation .

HY-N0136A

(±)-Taxifolin (±)-Dihydroquercetin	Autophagy Tyrosinase	Inflammation/Immunology
(±)-Taxifolin ((±)-Dihydroquercetin) is the racemate of Taxifolin. Taxifolin exhibits important anti-tyrosinase activity. Taxifolin exhibits significant inhibitory activity against collagenase with an IC₅₀ value of 193.3 μM . Taxifolin is an important natural compound with antifibrotic activity. Taxifolin is a free radical scavenger with antioxidant capacity .

HY-N10503

Norartocarpetin	Tyrosinase Ras Raf MAPKAPK2 (MK2) Apoptosis	Cancer
Norartocarpetin is a *tyrosinase* inhibitor. Norartocarpetin has strong tyrosinase inhibitory activity with an IC₅₀ value of 0.47 μM. Norartocarpetin as an antibrowning agent can be used for the research of food systems. Norartocarpetin also has a significant anticancer activity in lung carcinoma cells (NCI-H460) with an IC₅₀ value of 22 μM. Norartocarpetin has antiproliferative effects are mediated via targeting Ras/Raf/MAPK signalling pathway, mitochondrial mediated apoptosis, S-phase cell cycle arrest and suppression of cell migration and invasion in human lung carcinoma cells .

HY-W013571

4-Isopropylbenzoic acid	Fungal	Infection
4-Isopropylbenzoic acid, an aromatic monoterpenoid, is isolated from the stem bark of Bridelia retusa. 4-Isopropylbenzoic acid exhibits antifungal activities. 4-Isopropylbenzoic acid is also a reversible and uncompetitive inhibitor of mushroom tyrosinase .

HY-N0136B

(-)-Taxifolin (-)-Dihydroquercetin	Tyrosinase	Inflammation/Immunology
(-)-Taxifolin is the less active enantiomer of Taxifolin. Taxifolin exhibits important anti-tyrosinase activity. Taxifolin exhibits significant inhibitory activity against collagenase with an IC₅₀ value of 193.3 μM . Taxifolin is an important natural compound with antifibrotic activity. Taxifolin is a free radical scavenger with antioxidant capacity .

HY-Y0444

D-Tyrosine	Tyrosinase	Metabolic Disease
D-Tyrosine is the D-isomer of tyrosine. D-Tyrosine negatively regulates melanin synthesis by inhibiting *tyrosinase* activity. D-Tyrosine inhibits biofilm formation and trigger the self-dispersal of biofilms without suppressing bacterial growth .

HY-N3023

3,4-Dihydroxybenzylamine hydrobromide 1 Publications Verification NSC 263475 hydrobromide	DNA/RNA Synthesis	Cancer
3,4-Dihydroxybenzylamine hydrobromide (NSC 263475 hydrobromide) is an improved dopamine analog cytotoxic and inhibits DNA polymerase activity in melanoma cells . 3,4-Dihydroxybenzylamine hydrobromide (NSC 263475 hydrobromide) displays growth inhibitory activity in melanoma cell lines with varying degrees of tyrosinase activity .

HY-133680

β-Tocopherol	Tyrosinase	Metabolic Disease
β-Tocopherol is an analogue of vitamin E, exhibits antioxidant properties. β-Tocopherol can inhibit *tyrosinase* activity and melanin synthesis. β-Tocopherol also can prevent the inhibition of cell growth and of PKC activity caused by d-alpha-tocopherol .

HY-116750

6-Hydroxykaempferol	Tyrosinase	Others
6-Hydroxykaempferol, a flavonoid, is a competitive *tyrosinase* inhibitor with an IC₅₀ value of 124 μM. 6-Hydroxykaempferol has a K_i value of 148 μM relative to L-DOPA as a substrate and effectively inhibits the activity of the enzyme by binding to the active site of the enzyme .

HY-N1170

Taxiphyllin (2R)-Taxiphyllin	Others Tyrosinase	Others
Taxiphyllin (2R-Taxiphyllin) is a plant cyanogenic glycoside, which exhibits inhibitory activity for *tyrosinase* . Taxiphyllin exhibits cytotoxicity in BRL-3A cellls with an IC₅₀ of 18.75 μm and antimicrobial activities against Staphylococcus aureus with an EC₅₀ of 0.96 μM .

HY-N10016

Chlorogenic acid butyl ester	Tyrosinase	Cancer
Chlorogenic acid butyl ester, a caffeoylquinic acid, is a potent melanogenesis inhibitor. Chlorogenic acid butyl ester inhibits the expression of microphtalmia-associated transcription factor (MITF), *tyrosinase, tyrosinerelated protein 1 (TRP-1), and TRP-2. Chlorogenic acid butyl ester also shows antioxidant activity* .

HY-P3645

(Nle4)-α-MSH	Melanocortin Receptor	Others
(Nle4)-α-MSH is a synthetic analogue of α-MSH (HY-P0252), a melanocyte-stimulating hormone. (Nle4)-α-MSH reversibly darkens frog skins and also exhibits prolonged activity after heat-alkali treatment .

HY-N0136S

Taxifolin-d3 (+)-Dihydroquercetin-d₃; (+)-Taxifolin-d₃	Isotope-Labeled Compounds Autophagy Tyrosinase	Inflammation/Immunology
Taxifolin-d₃ is deuterium labeled Taxifolin. Taxifolin ((+)-Dihydroquercetin) exhibits important anti-tyrosinase activity. Taxifolin exhibits significant inhibitory activity against collagenase with an IC50 value of 193.3 μM[1]. Taxifolin is an important natural compound with antifibrotic activity. Taxifolin is a free radical scavenger with antioxidant capacity[2].

HY-113068

(rel)-β-Tocopherol	Tyrosinase	Metabolic Disease
(rel)-β-Tocopherol is a relative configuration of β-Tocopherol.(±)-β-Tocopherol is a lipid-soluble form of vitamin E with antioxidant activity. β-Tocopherol can inhibit tyrosinase activity and melanin synthesis. β-Tocopherol also can prevent the inhibition of cell growth and of PKC activity caused by d-alpha-tocopherol .

HY-N2472

Medicagenic acid Castanogenin	Bacterial	Infection
Medicagenic acid (Castanogenin) is isolated from the roots of Herniaria glabra, exhibits potent fungistatic effects against several plant pathogens and human dermatophytes . Medicagenic acid (Castanogenin) has low enzyme inhibitory activities, the target enzymes are xanthine oxidase, collagenase, elastase, tyrosinase, ChE .

HY-N2902

Artocarpin	Others	Cancer
Artocarpin is an isoprenoid-substituted flavonoid, that can be isolated from the wood of Artocarpus heterophyllus. Artocarpin inhibits melanin biosynthesis in B16 melanoma cells without inhibiting tyrosinase. The presence of the isoprenoid-substituted moiety enhanced the inhibitory activity on melanin production in B16 melanoma cells .

HY-N1780

3,4-Dimethoxyphenol
3,4-Dimethoxyphenol is a plant-derived phenylpropanoid compound and can use as a whitening agent in cosmetics. 3,4-Dimethoxyphenol has *tyrosinase*-inhibiting activity . 3,4-Dimethoxyphenol has potent antioxidant effect isolated from the bacterial fermentation broth .

HY-N1775

3',4'-Dihydroxyacetophenone 3,4-DHAP
3',4'-Dihydroxyacetophenone (3,4-DHAP), isolated from Picea Schrenkiana Needles exhibits a strong suppressive action against *tyrosinase* activity, with an IC₅₀ of 10 μM. 3',4'-Dihydroxyacetophenone (3,4-DHAP) is a vasoactive agent and antioxidant .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N6244

Isolindleyin	Classification of Application Fields Polygonaceae Source classification Rheum officinale Baill. Phenols Polyphenols Plants Disease Research Fields Inflammation/Immunology	Tyrosinase
Isolindleyin, a butyrophenone, is a *tyrosinase* inhibitor, with a K_d of 54.8 μM for human tyrosinase. Isolindleyin exhibits anti-inflammatory, analgesic and anti-melanogenic activities .

HY-N7929

5-Feruloylquinic acid	Monophenols other families Classification of Application Fields Ketones, Aldehydes, Acids Source classification Other Phenylpropanoids Phenols Phenylpropanoids Plants Disease Research Fields Cancer	Tyrosinase
5-Feruloylquinic acid (5-FQA) possesses antioxidative effects and tyrosinase inhibitory activities .

HY-N3091

Persiconin	Structural Classification Flavonoids Classification of Application Fields Flavonones Source classification Other Diseases Rosaceae Cosmetic Research Plants Disease Research Fields Amygdalus persica L.	Tyrosinase
Persiconin is a tyrosinase Inhibitor. Persiconin can be isolated from Prunus persica. Persiconin has tyrosinase inhibitory activity of 46% at 500 μM. Persiconin can be used in whitening research .

HY-N3200

Neorauflavane	Structural Classification Leguminosae Campylotropis hirtella (Franch.) Schindl. Source classification Phenols Polyphenols Plants	Tyrosinase
Neorauflavane is a potent *tyrosinase* inhibitor derived from Campylotropis hirtella, with an IC₅₀ value of 30 nM for tyrosinase monophenolase activity and an IC₅₀ value of 500 nM for diphenolase activity. Neorauflavane can effectively reduce the melanin content of B16 melanoma cells .

HY-N10286

Chetoseminudin B	Alkaloids Microorganisms Classification of Application Fields Source classification Other Diseases Disease Research Fields Indole Alkaloids	Tyrosinase
Chetoseminudin B possesses mushroom tyrosinase inhibitory activity with IC₅₀ of 31.7 μM .

HY-B1461

Deoxyarbutin	Structural Classification Natural Products Monophenols other families Classification of Application Fields Source classification Other Diseases Phenols Plants Disease Research Fields	Tyrosinase
Deoxyarbutin can effectively inhibit tyrosinase activity and melanin synthesis, thereby achieving significant and lasting whitening effects, and has a strong antioxidant effect.

HY-N3943

Glabrene	Stilbenes Leguminosae Source classification Phenols Polyphenols Plants Glycyrrhiza uralensis Fisch.	Tyrosinase
Glabrene, an isoflavene derived from licorice root, shows estrogen-like activity. Glabrene is a *tyrosinase* inhibitor with an IC₅₀ of 3.5 μM .

HY-N3912

Furomollugin	Natural Products Rubia podantha Source classification Rubiaceae Plants	Bacterial
Furomollugin is a natural product with antioxidant and antibacterial activities, can be isolated from Rubia cordifolia. Furomollugin lacks potent anti-tyrosinase activity, but also exhibits significant anticancer property .

HY-126052

Gnetol	Structural Classification Stilbenes Classification of Application Fields Source classification Phenols Polyphenols Metabolic Disease Gnetaceae Plants Disease Research Fields Gnetum montanum Markgr.	COX Tyrosinase HDAC
Gnetol is a phenolic compound isolated from the root of Gnetum montanum . Gnetol potently inhibits COX-1 (IC₅₀ of 0.78 μM) and HDAC. Gnetol is a potent *tyrosinase* inhibitor with an IC₅₀ of 4.5 μM for murine tyrosinase and suppresses melanin biosynthesis. Gnetol has antioxidant, antiproliferative, anticancer and hepatoprotective activity. Gnetol also possesses concentration-dependent α-Amylase, α-glucosidase, and adipogenesis activities .

HY-N3773

Dodoviscin A	Structural Classification Flavonoids Flavones Source classification Dodonaea viscosa (L.) Jacq. Sapindaceae Plants	Tyrosinase
Dodoviscin A is a pigmentation-altering agent, which can be isolated from the aerial parts of Dodonaea viscosa. Dodoviscin A inhibits melanin production in B16-F10 melanoma cells. Dodoviscin A suppresses mushroom tyrosinase activity, and **tyrosinase activity induced by 3-isobutyl-1-methylxanthine. Dodoviscin A also inhibits the phorphosylation of cAMP response element binding protein**, induced by 3-isobutyl-1-methylxanthine and forskolin .

HY-N0616

Trifolirhizin	Structural Classification Flavonoids Classification of Application Fields Leguminosae Source classification Plants Trifolium pratense Linn. Sophora flavescens Aiton Other Flavonoids Inflammation/Immunology Disease Research Fields Cancer	Tyrosinase
Trifolirhizin is a pterocarpan flavonoid isolated from the roots of Sophora flavescens. Trifolirhizin possesses potent *tyrosinase* inhibitory activity with an IC₅₀ of 506 μM . Trifolirhizin exhibits potential anti-inflammatory and anticancer activities .

HY-N2460

Aloesin 1 Publications Verification Aloeresin	Monophenols Liliaceae Classification of Application Fields Ketones, Aldehydes, Acids Source classification Phenols Aloe vera (L.) Burm. f. Plants Inflammation/Immunology Disease Research Fields	Tyrosinase Apoptosis
Aloesin (Aloeresin) is a *tyrosinase* inhibitor, and shows anti-inflammatory activity, ultraviolet protection, and antibacterium effects. Aloesin can induce apoptosis and be used in ovarian cancer research .

HY-N3674

Dalbergioidin	Structural Classification Leguminosae Source classification Phenols Polyphenols Plants Phaseolus vulgaris Linn.	TGF-beta/Smad
Dalbergioidin, a well-known anthocyanin, ameliorates doxorubicin-induced renal fibrosis by suppressing the TGF-β signal pathway. Dalbergioidin exhibits tyrosinase inhibitory activity with an IC₅₀ of 20 mM .

HY-N7587

Chlorophorin	Structural Classification Artocarpus xanthocarpus Source classification Phenols Polyphenols Plants Moraceae	Melanocortin Receptor
Chlorophorin is a inhibitor of Melanocortin Receptor. Chlorophorin reduces tyrosinase activity and inhibits a-melanocyte-stimulating hormone-induced melanin production in B16F10 melanoma cells .

HY-N10285

Phaeosphaone D	Infection Alkaloids Microorganisms Classification of Application Fields Source classification Disease Research Fields Indole Alkaloids	Tyrosinase
Phaeosphaone D is a thiodiketopiperazine alkaloid compound isolated from Phaeosphaeria fuckelii, an endophytic fungus. Phaeosphaone D displays mushroom tyrosinase inhibitory activity with an IC₅₀ value of 33.2 μM .

HY-W019829

Polyphyllin C	Infection other families Classification of Application Fields Source classification Plants Disease Research Fields Steroids	Tyrosinase Parasite
Polyphyllin C (compound 2) is a spirostanol saponin. Polyphyllin C exhibits mild (IC₅₀=36.87 µM) activities against the *tyrosinase* and moderate (IC₅₀=1.59 µg/mL) antileishmanial activities .

HY-N0136

Taxifolin Maximum Cited Publications 11 Publications Verification (+)-Dihydroquercetin; (+)-Taxifolin	Flavanonols Flavonoids other families Classification of Application Fields Anti-aging Source classification Phenols Polyphenols Plants Disease Research Fields Inflammation/Immunology	Autophagy Tyrosinase
Taxifolin ((+)-Dihydroquercetin) exhibits important anti-tyrosinase activity. Taxifolin exhibits significant inhibitory activity against collagenase with an IC₅₀ value of 193.3 μM . Taxifolin is an important natural compound with antifibrotic activity. Taxifolin is a free radical scavenger with antioxidant capacity .

HY-N0637A

(±)-Eriodictyol (±)-Huazhongilexone; Dihydroluteolin	Structural Classification Flavonoids Lythraceae Lawsonia inermis L. Flavones Source classification Plants	Melanocortin Receptor
(±)-Eriodictyol ((±)-Huazhongilexone), a flavonoid, is a potent melanogenesis inhibitor with an IC₅₀ of 48 μM. (±)-Eriodictyol suppresses tyrosinase, TRP-1, and TRP-2 mRNA expression. (±)-Eriodictyol has strong anti-plasmin activities .

HY-N3518

Mulberroside F	Structural Classification Monophenols other families Classification of Application Fields Whitening Agent Source classification Phenols Metabolic Disease Cosmetic Research Plants Disease Research Fields	Tyrosinase
Mulberroside F is one of the main bioactive constituents in mulberry (Morus alba L.) . Mulberroside F shows inhibitory effects on *tyrosinase* activity and on the melanin formation. Mulberroside F also exhibits superoxide scavenging activity that is involved in the protection against auto-oxidation .

HY-N0136A

(±)-Taxifolin (±)-Dihydroquercetin	Flavanonols Flavonoids other families Classification of Application Fields Source classification Phenols Polyphenols Plants Disease Research Fields Inflammation/Immunology	Autophagy Tyrosinase
(±)-Taxifolin ((±)-Dihydroquercetin) is the racemate of Taxifolin. Taxifolin exhibits important anti-tyrosinase activity. Taxifolin exhibits significant inhibitory activity against collagenase with an IC₅₀ value of 193.3 μM . Taxifolin is an important natural compound with antifibrotic activity. Taxifolin is a free radical scavenger with antioxidant capacity .

HY-N10503

Norartocarpetin	Structural Classification Flavonoids Flavones Plants Moraceae	Tyrosinase Ras Raf MAPKAPK2 (MK2) Apoptosis
Norartocarpetin is a *tyrosinase* inhibitor. Norartocarpetin has strong tyrosinase inhibitory activity with an IC₅₀ value of 0.47 μM. Norartocarpetin as an antibrowning agent can be used for the research of food systems. Norartocarpetin also has a significant anticancer activity in lung carcinoma cells (NCI-H460) with an IC₅₀ value of 22 μM. Norartocarpetin has antiproliferative effects are mediated via targeting Ras/Raf/MAPK signalling pathway, mitochondrial mediated apoptosis, S-phase cell cycle arrest and suppression of cell migration and invasion in human lung carcinoma cells .

HY-W013571

4-Isopropylbenzoic acid	Infection other families Classification of Application Fields Bridelia retusa Ketones, Aldehydes, Acids Source classification Euphorbiaceae Plants Disease Research Fields	Fungal
4-Isopropylbenzoic acid, an aromatic monoterpenoid, is isolated from the stem bark of Bridelia retusa. 4-Isopropylbenzoic acid exhibits antifungal activities. 4-Isopropylbenzoic acid is also a reversible and uncompetitive inhibitor of mushroom tyrosinase .

HY-N0136B

(-)-Taxifolin (-)-Dihydroquercetin	Flavanonols Flavonoids other families Classification of Application Fields Source classification Phenols Polyphenols Plants Disease Research Fields Inflammation/Immunology	Tyrosinase
(-)-Taxifolin is the less active enantiomer of Taxifolin. Taxifolin exhibits important anti-tyrosinase activity. Taxifolin exhibits significant inhibitory activity against collagenase with an IC₅₀ value of 193.3 μM . Taxifolin is an important natural compound with antifibrotic activity. Taxifolin is a free radical scavenger with antioxidant capacity .

HY-Y0444

D-Tyrosine	Structural Classification Monophenols Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Phenols Metabolic Disease Endogenous metabolite Disease Research Fields	Tyrosinase
D-Tyrosine is the D-isomer of tyrosine. D-Tyrosine negatively regulates melanin synthesis by inhibiting *tyrosinase* activity. D-Tyrosine inhibits biofilm formation and trigger the self-dispersal of biofilms without suppressing bacterial growth .

HY-133680

β-Tocopherol	Monophenols Classification of Application Fields Source classification Phenols Metabolic Disease Plants Palmae Disease Research Fields Trachycarpus fortunei (Hook.) H. Wendl.	Tyrosinase
β-Tocopherol is an analogue of vitamin E, exhibits antioxidant properties. β-Tocopherol can inhibit *tyrosinase* activity and melanin synthesis. β-Tocopherol also can prevent the inhibition of cell growth and of PKC activity caused by d-alpha-tocopherol .

HY-116750

6-Hydroxykaempferol	Structural Classification Flavonols Flavonoids Trifolium repens Linn. Leguminosae Source classification Plants	Tyrosinase
6-Hydroxykaempferol, a flavonoid, is a competitive *tyrosinase* inhibitor with an IC₅₀ value of 124 μM. 6-Hydroxykaempferol has a K_i value of 148 μM relative to L-DOPA as a substrate and effectively inhibits the activity of the enzyme by binding to the active site of the enzyme .

HY-N1170

Taxiphyllin (2R)-Taxiphyllin	Structural Classification Hydrangeaceae Source classification Phenols Plants	Others Tyrosinase
Taxiphyllin (2R-Taxiphyllin) is a plant cyanogenic glycoside, which exhibits inhibitory activity for *tyrosinase* . Taxiphyllin exhibits cytotoxicity in BRL-3A cellls with an IC₅₀ of 18.75 μm and antimicrobial activities against Staphylococcus aureus with an EC₅₀ of 0.96 μM .

HY-N10016

Chlorogenic acid butyl ester	Structural Classification Lysimachia davurica Ledeb. Source classification Phenols Polyphenols Plants Primulaceae	Tyrosinase
Chlorogenic acid butyl ester, a caffeoylquinic acid, is a potent melanogenesis inhibitor. Chlorogenic acid butyl ester inhibits the expression of microphtalmia-associated transcription factor (MITF), *tyrosinase, tyrosinerelated protein 1 (TRP-1), and TRP-2. Chlorogenic acid butyl ester also shows antioxidant activity* .

HY-113068

(rel)-β-Tocopherol	Structural Classification Monophenols Microorganisms Classification of Application Fields Source classification Agrostidoideae Phenols Metabolic Disease Plants Disease Research Fields Triticum aestivum L.	Tyrosinase
(rel)-β-Tocopherol is a relative configuration of β-Tocopherol.(±)-β-Tocopherol is a lipid-soluble form of vitamin E with antioxidant activity. β-Tocopherol can inhibit tyrosinase activity and melanin synthesis. β-Tocopherol also can prevent the inhibition of cell growth and of PKC activity caused by d-alpha-tocopherol .

HY-N2472

Medicagenic acid Castanogenin	Infection Triterpenes Structural Classification Classification of Application Fields Herniaria glabra Linnaeus. Terpenoids Plants Disease Research Fields Caryophyllaceae	Bacterial
Medicagenic acid (Castanogenin) is isolated from the roots of Herniaria glabra, exhibits potent fungistatic effects against several plant pathogens and human dermatophytes . Medicagenic acid (Castanogenin) has low enzyme inhibitory activities, the target enzymes are xanthine oxidase, collagenase, elastase, tyrosinase, ChE .

HY-N2902

Artocarpin	Structural Classification Flavonols Flavonoids Source classification Plants Moraceae	Others
Artocarpin is an isoprenoid-substituted flavonoid, that can be isolated from the wood of Artocarpus heterophyllus. Artocarpin inhibits melanin biosynthesis in B16 melanoma cells without inhibiting tyrosinase. The presence of the isoprenoid-substituted moiety enhanced the inhibitory activity on melanin production in B16 melanoma cells .

HY-N4005

Isoastilbin	Flavanonols Flavonoids other families Source classification Phenols Polyphenols Plants	Bacterial Tyrosinase
Isoastilbin is a dihydroflavonol glycoside compound in Rhizoma Smilacis glabrae and Astragalus membranaceus. Isoastilbin inhibits glucosyltransferase (GTase) with an IC₅₀ value of 54.3 μg/mL, and also inhibits *tyrosinase* activity. Isoastilbin shows neuroprotective, antioxidation, antimicrobial and anti-apoptotic properties and has the potential for Alzheimer’s disease research .

HY-W017212

Methyl cinnamate Methyl 3-phenylpropenoate	Microorganisms Classification of Application Fields Simple Phenylpropanols Source classification Rutaceae Metabolic Disease Phenylpropanoids Plants Disease Research Fields Zanthoxylum armatum DC.	Tyrosinase Bacterial AMPK
Methyl cinnamate (Methyl 3-phenylpropenoate), an active component of Zanthoxylum armatum, is a widely used natural flavor compound. Methyl cinnamate (Methyl 3-phenylpropenoate) possesses antimicrobial activity and is a *tyrosinase* inhibitor that can prevent food browning. Methyl cinnamate (Methyl 3-phenylpropenoate) has antiadipogenic activity through mechanisms mediated, in part, by the CaMKK2-AMPK signaling pathway .

HY-N0619

Mulberroside A 2 Publications Verification	Structural Classification Stilbenes Classification of Application Fields Source classification Phenols Polyphenols Morus alba L. Plants Moraceae Inflammation/Immunology Disease Research Fields	TNF Receptor Interleukin Related Tyrosinase
Mulberroside A is one of the main bioactive constituent in mulberry (Morus alba L.) . Mulberroside A decreases the expressions of TNF-α, IL-1β, and IL-6 and inhibits the activation of NALP3, caspase-1, and NF-κB and the phosphorylation of ERK, JNK, and p38, exhibiting anti-inflammatory antiapoptotic effects . Mulberroside A shows inhibitory activity against mushroom *tyrosinase* with an IC₅₀ of 53.6 μM .

HY-N0619A

cis-Mulberroside A Mulberroside D	Stilbenes Classification of Application Fields Source classification Phenols Polyphenols Plants Moraceae Inflammation/Immunology Disease Research Fields Morus alba Linn.	TNF Receptor Interleukin Related Tyrosinase
cis-Mulberroside A (Mulberroside D) is the cis-isomer of Mulberroside A. Mulberroside A is one of the main bioactive constituent in mulberry (Morus alba L.) . Mulberroside A decreases the expressions of TNF-α, IL-1β, and IL-6 and inhibits the activation of NALP3, caspase-1, and NF-κB and the phosphorylation of ERK, JNK, and p38, exhibiting anti-inflammatory and anti-apoptotic effects . Mulberroside A shows inhibitory activity against mushroom *tyrosinase* with an IC₅₀ of 53.6 μM .

HY-N2983

Cajanin	Flavonoids Classification of Application Fields Leguminosae red seaweeds Source classification Other Diseases Phenols Polyphenols Plants Disease Research Fields Isoflavones	Tyrosinase
Cajanin is a potent and orally active anti-melanogenic agent. Cajanin shows antiproliferative activity in MNT1 Cells. Cajanin efficiently decreases the melanin content. Cajanin down-regulates the mRNA and protein expression levels of MITF, tyrosinase, TRP-1 and Dct (TRP-2). Cajanin induces cell cycle arrest at G2/M and S phase. Cajanin stimulates osteoblast proliferation. Cajanin has the potential for the research of human hyperpigmented disorders and menopausal osteoporosis .

Cat. No.	Product Name	Chemical Structure

HY-Y0444S1

D-Tyrosine-d4
D-Tyrosine-d₄ is the deuterium labeled D-Tyrosine. D-Tyrosine is the D-isomer of tyrosine. D-Tyrosine negatively regulates melanin synthesis by inhibiting tyrosinase activity. D-Tyrosine inhibits biofilm formation and trigger the self-dispersal of biofilms without suppressing bacterial growth[1][2].

HY-N0136S

Taxifolin-d3
Taxifolin-d₃ is deuterium labeled Taxifolin. Taxifolin ((+)-Dihydroquercetin) exhibits important anti-tyrosinase activity. Taxifolin exhibits significant inhibitory activity against collagenase with an IC50 value of 193.3 μM[1]. Taxifolin is an important natural compound with antifibrotic activity. Taxifolin is a free radical scavenger with antioxidant capacity[2].

HY-Y0444S

D-Tyrosine-d2
D-Tyrosine-d₂ is the deuterium labeled D-Tyrosine. D-Tyrosine is the D-isomer of tyrosine. D-Tyrosine negatively regulates melanin synthesis by inhibiting tyrosinase activity. D-Tyrosine inhibits biofilm formation and trigger the self-dispersal of biofilms without suppressing bacterial growth[1][2].

HY-Y0444S2

D-Tyrosine-d7
D-Tyrosine-d₇ is the deuterium labeled D-Tyrosine. D-Tyrosine is the D-isomer of tyrosine. D-Tyrosine negatively regulates melanin synthesis by inhibiting tyrosinase activity. D-Tyrosine inhibits biofilm formation and trigger the self-dispersal of biofilms without suppressing bacterial growth[1][2].

HY-113068S

β-Tocopherol-d3
β-Tocopherol-d₃ is the deuterium labeled β-Tocopherol. β-Tocopherol is an analogue of vitamin E, exhibits antioxidant properties. β-Tocopherol can inhibit tyrosinase activity and melanin synthesis. β-Tocopherol can also prevent the inhibition of cell growth and of PKC activity caused by d-alpha-tocopherol[1][2][3].

HY-N0136S1

(±)-Taxifolin-13C3

(±)-Taxifolin-13C3 ((±)-Dihydroquercetin-13C3) is a derivative of (±)-Taxifolin, labeled with 13C3. (±)-Taxifolin is the racemate of Taxifolin. Taxifolin exhibits important anti-tyrosinase activity. Taxifolin exhibits significant inhibitory activity against collagenase with an IC₅₀ value of 193.3 μM . Taxifolin is an important natural compound with antifibrotic activity. Taxifolin is a free radical scavenger with antioxidant capacity .

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks